Hepatitis B

What is hepatitis B?

• context Hepatitis B is an infectious liver disease. It is caused by the hepatitis B virus (HBV). Infections of hepatitis B occur only if the virus is able to enter the bloodstream and reach the liver. Once in the liver, the virus reproduces and releases large numbers of new viruses into the bloodstream.
• context To combat the disease, the body has several defences. White blood cells, which protect the body from infections, attack and destroy the infected liver cells. The body also produces antibodies which circulate in the blood to destroy the virus and protect against future infections of hepatitis B. During the infection and recovery process, the liver may not function normally, causing illness that affects the entire body.
• context For reasons that are not completely understood, 10 percent of people who develop hepatitis B become carriers of the disease. Their blood remains infected for months, years, or sometimes for life. Seventy percent of carriers develop chronic persistent hepatitis B. Most do not appear to be ill. The remaining 30 percent of carriers experience continuous liver disease. This condition often progresses to cirrhosis and then, after 30 to 40 years, possibly to liver cancer. At present, there is no way of curing carriers. The risk of becoming a chronic carrier is related inversely to a person's age when infected. For example, the risk of an infant becoming a carrier is 90-95%, whereas the risk of an adult becoming a carrier is 3-10%.
• context There are other kinds of viral hepatitis, such as hepatitis A, hepatitis C, hepatitis D (delta), and hepatitis E. These diseases and the viruses that cause them are not related to hepatitis B, even though they also affect the liver.

How long does it take for hepatitis B to develop?

• context The incubation period (the time between initial contact with the virus and onset of the disease) for hepatitis B ranges from 60 to 150 days, with symptoms beginning on average 90 days from exposure. Sometimes, symptoms appear after 2 weeks.

How common is it?

• context In Canada in 2020, the rate was 8.2 cases per 100,000 people, as reported by the Public Health Agency of Canada (published in 2023). This rate was less than in pre-COVID-19 pandemic years.

Where is the hepatitis B virus found, and how is it transmitted?

Blood is the major source of the hepatitis B virus in the workplace. It can also be found in other tissues and body fluids. The risk of transmission varies according to the specific source. The virus can survive outside the body for at least 7 days and still be able to cause infection.

Blood

Direct contact with infected blood can transmit the hepatitis B virus through: To a lesser extent, indirect contact with blood-contaminated surfaces can also transmit the hepatitis B virus. The virus may be stable in dried blood for up to 7 days at 25°C. Hand contact with blood-contaminated surfaces such as laboratory benches, test tubes, or laboratory instruments may transfer the virus to skin or mucous membranes. Shared or unsterilized medical or dental equipment or equipment used for tattooing, body piercing, or acupuncture can be a concern for transmission.

• context Punctures of the skin with blood-contaminated needles, lancets, scalpels, or other sharps.
• context Direct contact with open sores of an infected person.
• context Splashes to skin bearing minute scratches, abrasions, burns, or even minor rashes.
• context Splashes to mucous membranes in the mouth, nose, or eyes.

Saliva

• context The saliva of people with hepatitis B can contain the hepatitis B virus, but in very low concentrations compared with blood. Injections of infected saliva can transmit the virus, meaning bite injuries can also spread the disease. There are no reports of people getting hepatitis B from mouth contact with infected cardiopulmonary resuscitation (CPR) manikins, sharing utensils, or mouthpieces of musical instruments.

Other Body Fluids and Tissues

• context Hepatitis B is found in semen and vaginal secretions. The virus can be transmitted during unprotected sexual intercourse and from mother to infant during birth.
• context Synovial fluid (joint lubricant), amniotic fluid, cerebrospinal fluid, and peritoneal fluid (found in the abdominal cavity) can contain the hepatitis B virus, but the risk of transmission to workers is not known.
• context Feces, nasal secretions, sputum, sweat, tears, urine, and vomit have not been implicated in the spread of hepatitis B. Unless they are visibly contaminated with blood, the risk of contracting hepatitis B from these fluids in the workplace is very low.
• context Hepatitis B is not transmitted by casual contact. For example, hospital employees who have no contact with blood, blood products, or blood-contaminated fluids are at no greater risk than the general public. However, the virus can spread through intimate contact with carriers in a household setting, possibly because of frequent physical contact with small cuts or skin rashes. The virus can also spread through biting and possibly by the sharing of toothbrushes or razors. It is not spread through sneezing, coughing, hand holding, hugging, kissing, breastfeeding, sharing eating utensils, water or food.

What occupations have an increased risk of hepatitis B?

In general, occupational groups with increased risk include: Travellers to regions with intermediate or high rates of endemic hepatitis B virus infection (where it is found among many people in that area) may also consider being vaccinated.

• context Healthcare workers who are repeatedly exposed to blood or blood products or those who are at risk of needlestick injury.
• context Pathologists, laboratory personnel, or embalmers.
• context Dentists, dental assistants, and dental hygienists.
• context Staff of institutions where workers may be exposed to aggressive, biting residents or patients.
• context Tattooists, body piercers, or those who perform acupuncture.

What are the symptoms of hepatitis B?

• context Signs and symptoms can vary, in particular, by the age of the individual. Many individuals may not show symptoms (be asymptomatic) or only have mild symptoms. Symptoms may take 2 to 5 months to appear. When symptoms develop for acute hepatitis B, they include fever, joint pain, abdominal pain, fatigue, lack of appetite, nausea, vomiting, dark urine, clay-coloured bowel movements, or jaundice (yellowing of the skin and eyes).
• context About 90 to 95 percent of adults with acute hepatitis B will recover on their own in about 6 months and develop lifelong protection.
• context Some people will not recover and will develop a long-lasting infection known as chronic hepatitis B. Infants and children under 4 years are at particular risk.
• context Most infections are asymptomatic or mild. Occasionally, people with serious cases of hepatitis B require hospitalization. A very small proportion of these patients develop a critical form of the disease called "fulminant" hepatitis B. This condition results from a sudden breakdown of liver function.

What laboratory tests are available for hepatitis B?

• context Tests are available to detect the types of antigens used to identify the hepatitis B virus. The tests determine if the virus is present in the body tissue or blood. The amount of each type of antigen present indicates how advanced the disease is and how infective the individual has become.
• context Other tests are available to detect the body's reaction to the viral infection or the body's reaction to vaccination against the virus. These tests work by measuring the number of antibodies present in the blood.

What is the treatment for hepatitis B?

Prevention is recommended by receiving a vaccine for the hepatitis B virus. Receiving an injection of the hepatitis B immune globulin within 12 hours of coming in contact with the virus may help prevent the development of the disease. At present, there is no specific treatment for patients with acute hepatitis B. Acute infection is usually short and will often resolve on its own. Your healthcare provider may recommend rest, adequate nutrition, and fluids to help your body fight the infection. Hospitalization may be required for patients who suffer from severe vomiting and who are unable to maintain adequate nutritional levels. It may also be required to prevent the development of complications. While chronic infection cannot be cured, there are two standard treatments in Canada that may control the virus and prevent further damage to the liver. Untreated chronic hepatitis B may result in cirrhosis (scarring of the liver), liver failure, or liver cancer. A reactivation of the hepatitis B virus may occur if a person uses immunosuppressive medications. Physicians may do regular monitoring for signs of liver disease progression. A liver transplant may be recommended if the liver is severely damaged.

• context Antiviral medications can fight the virus and slow damage to the liver.
• context Interferon, which may be given for short periods and, if effective, results in suppression of the virus.